(2-methoxyethyl)benzene

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

of read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

Principles of method if other than guideline:

WoE 1 report is based on two short term toxicity study of aquatic invertebrate for the test chemical :
WoE-2 and WoE- 3

GLP compliance:

not specified

Analytical monitoring:

not specified

Test organisms (species):

Daphnia magna

Details on test organisms:

2 & 3:
- Common name: Water flea
3:
- source: BASF AG Ludwigshafen

Water media type:

freshwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

230 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 2

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

125 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 3

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

287.17 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 3

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

500 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 3

Validity criteria fulfilled:

not specified

Conclusions:

Study was conducted to determine effect of test chemical on aquatic invertebrates. Based on effect of test chemical on mobility of the test organism , the 48 h EC0 was determined to be 125 mg/l and EC50 value ranges from 230- 287.17 mg/l while EC100 determined to be 500 mg/l.

Executive summary:

Data available for the structurally and functionally similar read across substance has been reviewed to determine the short term toxicity of aquatic invertebrate .The studies are as mentioned below:

In first study, short term toxicity to aquatic Invertebrate was conducted for 48hrs for assessing the effect of test chemical on test organism. Thus, effect of test chemical on mobility of the test organism Daphnia magna,the 48 hr EC50 value was determined to be 230 mg/L. Based on the above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.

In last study, short term toxicity to aquatic Invertebrate was conducted for 48hrs for assessing the effect of test chemical on test organism. Daphnia magna was used as a test organism for the study. Thus, effect of test chemical on mobility of the test organism, the  48 hr  EC0, EC50 and EC100 values were determined to be 125, 287.17 and 500 mg/l respectively. Based on the above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.

On the basis of above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.

Description of key information

Short-term toxicity to aquatic invertebrates:

Study was conducted to determine effect of test chemical on aquatic invertebrates. Based on effect of test chemical on mobility of the test organism , the 48 h EC0 was determined to be 125 mg/l and EC50 value ranges from 230- 287.17 mg/l while EC100 determined to be 500 mg/l.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

189.2 mg/L

Additional information

Short-term toxicity to aquatic invertebrates:

Data available for the structurally and functionally similar read across substance has been reviewed to determine the short term toxicity of aquatic invertebrate .The studies are as mentioned below:

In first study, short term toxicity to aquatic Invertebrate was conducted for 48hrs for assessing the effect of test chemicalon test organism. Thus, effect of test chemical on mobility of the test organism Daphnia magna,the 48 hr EC50 value was determined to be 230 mg/l .Based on the above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.

In last study, short term toxicity to aquatic Invertebrate was conducted for 48hrs for assessing the effect of test chemicalon test organism. Daphnia magna was used as a test organism for the study. Thus, effect of test chemical on mobility of the test organism, the  48 hr  EC0, EC50 and EC100 value was determined to be 125, 287.17 and 500 mg/l respectively..Based on the above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.

On the basis of above value, chemical can be considered as non-toxic to aquatic invertebrates and can be considered to be ‘’not classified’’ as per CLP classification criteria.