Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-793-7 | CAS number: 541-85-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, acceptable for assessment. However no guideline was followed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Recherche de relations entre toxicité de molécules d'interêt industriel et propriétés physico-chimiques: Test d'irritation des voies aériennes supérieures appliqué à quatre familles chimiques
- Author:
- Muller J., Greff G.
- Year:
- 1 984
- Bibliographic source:
- Fd. chem. Toxic. vol. 2., Nr 8., p661-664, 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Measurement of the change in the breathing frequency of mice in the presence of the test substance was tested to indicate a sensory irritation to the upper repiratory tract using the Alarie assay.
- GLP compliance:
- no
Test material
- Reference substance name:
- Méthyl-5-heptan-3-one
- IUPAC Name:
- Méthyl-5-heptan-3-one
- Test material form:
- other: vaporized compound
Constituent 1
Results and discussion
Any other information on results incl. tables
The concentration of the tested substance diminishing the repiratory frequency to 50% (RD50) was 3980 mg/m3.
Applicant's summary and conclusion
- Conclusions:
- Methyl-5-heptan-3-one diminished the respiratory rate of mice .
- Executive summary:
Respiratory irritation to 5-methylheptan-3-one was tested by measuring the change in the breathing frequency of mice in the presence of the tested substance to indicate a sensory irritation to the upper repiratory tract. 6 mice were restrained in body plethysmographs to measure the respiratory rate while the head of the mouse was extended into a 200-Liter inhalation chamber maintained which contained the tested substance at the required concentration. 4 exposure concentrations of 5-methylheptan-3-one were tested. From the data obtained, a concentration-effect curve was extrapolated and fitted. From the equation, the concentration of the tested substance diminishing the repiratory frequency to 50% was calculated to be 3980 mg/m3. The results confirms the classification of the test substance 5-methylheptan-3-one in the Annex VI of the Regulation (EC) 1272/2008 as respiratory irritating (STOT SE 3, H335).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
