Registration Dossier
Registration Dossier
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EC number: 208-793-7 | CAS number: 541-85-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Type of study / information:
- Observations after inhalative exposure of volunteers for 5 minutes.
Test material
- Reference substance name:
- 5-methylheptan-3-one
- EC Number:
- 208-793-7
- EC Name:
- 5-methylheptan-3-one
- Cas Number:
- 541-85-5
- Molecular formula:
- C8H16O
- IUPAC Name:
- 5-methylheptan-3-one
Constituent 1
Method
- Ethical approval:
- not specified
- Exposure assessment:
- measured
- Details on exposure:
- Exposure of volunteers to 5, 25, 50 and 100 ppm (27, 133, 266, 533 mg/m3) for 5 minutes
Results and discussion
- Results:
- - No symptoms were observed at a concentration of 27 mg/m3
- Volunteers complained of a mild nasal irritation at 133 mg/mg3
- Eye, nose and throat irritations occured at 266 mg/m3
- At concentration of 533 mg/m3, strong local irritation, headache and nausea were observed
Applicant's summary and conclusion
- Conclusions:
- Based on the observations, an indicative occupational exposure limit (IOEL) value of 53 mg/m3 was recommended.
- Executive summary:
Volunteers were exposed to different levels of 5 -methylheptan-3 -one for 5 minutes. Based on the observations, an indicative occupational exposure limit (IOEL) value of 53 mg/m3 was recommended.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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