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EC number: 303-553-9 | CAS number: 94200-74-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
96h EC50 (Pseudokirchnerella subcapitata; growth rate) = 117 mg/L (nominal concentration)
96h EC10 (Pseudokirchnerella subcapitata; growth rate) = 12 mg/L (nominal concentration)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 117 mg/L
- EC10 or NOEC for freshwater algae:
- 12 mg/L
Additional information
Since no reliable aquatic algae test is available for C12-isoAS Na (CAS 94200-74-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related category member was conducted. Read-across data from another C12 homologue - C12SA Na (CAS 151-21-3) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that the toxic effects are comparable for all the C12 homologues and the influence of the counter ion can be neglected.
The GLP compliant study was performed according to DIN 38412, part 9 guideline (Rieche 1994). Aquatic algae of Desmodesmus subspicatus species were exposed for 72 hours to four test concentrations up to 120 mg/L as nominal concentrations. Analytical check of test concentrations showed that the nominal concentrations were in agreement with the measured ones and therefore the nominal concentrations were used. The 72-h EC50 value for growth rate was above 120 mg/L (nominal concentration). The NOEC value for biomass was 30 mg/L (nominal concentration). These results are supported by a publication of Nyholm and Damgaard (1990). The non-GLP test was performed with Pseudokirchnerella subcapitata exposed to six test concentrations. No special guideline was followed and analytical monitoring of test concentrations was not performed. Growth rate measurement after 96-h resulted in the ErC50 value of 117 mg/L (nominal concentration). The EC10 for growth rate was 12 mg/L (nominal concentration). The study of Nyholm and Damgaard (1990) resulted in more conservative toxicity valeus, and therefore the EC10 of 12 mg/L and EC50 of 117 mg/L (both for growth rate) are considered as the reliable values for aquatic algae for C12-iso AS Na (CAS 94200-74-5).
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