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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

7d NOEC (Ceriodaphnia dubia; reproduction) = 0.88 mg/L (measured concentration, EPA-600/489/001)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.88 mg/L

Additional information

Since no reliable chronic test involving aquatic invertebrates is available for C12-isoAS Na (CAS 94200-74-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related category member was conducted. Read-across data from another C12 homologue - C12AS Na (CAS 151-21-3) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that the toxic effects are comparable for all the C12 homologues and the influence of counter ion can be neglected.

A non-GLP, 7-day reproduction toxicity test with Ceriodaphnia dubia performed according to EPA-600/489/001 guideline is available for CAS 151-21-3 (Lauth 1996). Daphnids were exposed under flow-through conditions to five test concentrations up to 8 mg/L. Analytical check of test concentration proved that the nominal concentrations were in agreement with the measured ones. Mortality and reproduction were evaluated daily. The NOEC value determined after 7 days of exposure to test substance was 0.88 mg/L (measured concentration). This result is supported by a publication from LeBlanc (1982). In this non-GLP, 40-day test Daphnia magna was exposed to the test substance up to 8 mg/L (nominal concentration) over four consecutive generations under semi-static conditions. No special guideline was followed. Offspring daphnids of less than 24 hours of age were collected after 10 days of exposure to the test substance and exposed for another 10 days. This procedure was repeated three times. The overall NOEC ranged from 2 to 4 mg/L (nominal concentrations, analytics not performed).

Due to structural and property similarities with the tested category member it can be concluded the above results apply also to C12-isoAS Na (CAS 94200-74-5). Since the result of Ceriodaphnia reproduction test was the lowest chronic aquatic effect value, the NOEC of 0.88 mg/L was used for PNEC calculation.