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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
A sensitive mouse lymph node assay with two application phases for detection of contact allergens.
Author:
Ikarashi, Y. et al.
Year:
1993
Bibliographic source:
Arch Toxicol 67, 629 - 636
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Deviations:
yes
Remarks:
e.g. limited data on test substance available, only 3 insead of 4 animals per group
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Reference substance name:
Sodium dodecyl sulphate
EC Number:
205-788-1
EC Name:
Sodium dodecyl sulphate
Cas Number:
151-21-3
IUPAC Name:
sodium dodecyl sulfate
Details on test material:
- Name of test material (as cited in study report): No data
- Physical state: No data
- Analytical purity: No data
- Lot/batch No.: No data
- Storage condition of test material: No data

In vivo test system

Test animals

Species:
mouse

Study design: in vivo (LLNA)

No. of animals per dose:
3

Results and discussion

Any other information on results incl. tables

Stimulation indices: a.) 0.73, 1.61 and 1.13; b.) 1.58, 1.93 or 1.48

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU