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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no guideline available
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
500, 1000, 1500, 1750, 1850, 2000, 2550 mg/kg
No. of animals per sex per dose:
15 males per dose group.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 790 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 14 days

Any other information on results incl. tables

Oral administration

Administration was performed by means of a gavage.

Male rats

A.I. dose

mg/kg

Toxicological Results

after 14 days

Signs of

intoxication

Died

after no.

days

start

end

500

0/15

-

-

-

1000

0/15/15

2h

2d

-

1500

0/15/15

2h

2d

-

1750

4/15/15

2h

3d

1-3

1850

11/15/15

1.5h

2d

1

2000

12/15/15

Ih

3d

1-2

2250

15/15/15

Ih

-

1

 

Results: DL50 (14 days) 1790 mg A.I./kg (1700-1890)

S = 1.1

Highest dose without findings: 500 mg/kg

Lowest lethal dose: 1750 mg/kg

Applicant's summary and conclusion

Interpretation of results:
other: classified as harmful (Acute Tox.4) according to the CLP Regulation (EC) No.1272/2008
Conclusions:
The DL50 in male rats (14 days) 1790 mg A.I./ kg (1700-1890).
Executive summary:

The toxicity of the substance after single exposure of rats was evaluated after the exposure of male Wistar rats to the substance at the concentrations 500, 1000, 1500, 1750, 1850, 2000, 2550 mg/kg bw.

The LD50 was found as 1790 mg/kg