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Description of key information

hydrolytically stable at pH 4.0, 7.0 and 9.0

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

The hydrolysis of the substance was studied in accordance with the OECD Testing Guideline 111 and under the GLP.

The samples were incubated for 5 days at 50 °C at pH 4.0, pH 7.0 and pH 9.0 sterile aqueous buffer solutions in dark conditions. At the

beginning of the test and at the end of the test, duplicate samples were analyzed by HPLC with UV detection to quantify the three components of interest of the test substance (mono,-di and tri-) presents in the aqueous samples.

Less than 10 % degradation of the substance was observed after 5 days incubation at 50.0 °C in sterile pH 4.0, pH 7.0 and pH 9.0 buffer samples. The tri- at pH 4 showed a drop of 10.91 %; however this was not deemed significant when the standard error of the results and the concentration of this compound in the test item was taken into account.

The test substance was considered to be hydrolytically stable at pH 4.0, 7.0 and 9.0 and no additional testing was required or performed.