Registration Dossier
Registration Dossier
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EC number: 233-653-7 | CAS number: 10294-26-5
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Remarks:
- percutaneous absorption in guiena pigs
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Reasonably well-documented publication, despite major methodological deficiencies.
Data source
Reference
- Reference Type:
- publication
- Title:
- Percutaneous toxicity of metal compounds. A comparative investigation in guinea pigs.
- Author:
- Wahlberg, R.C.; et al.
- Year:
- 1 965
- Bibliographic source:
- Arch. Environ. Health 11, 201-204
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Silver nitrate
- EC Number:
- 231-853-9
- EC Name:
- Silver nitrate
- Cas Number:
- 7761-88-8
- Molecular formula:
- AgNO3
- IUPAC Name:
- Silver nitrate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- guinea pig
- Details on test animals or test system and environmental conditions:
- Guinea pig with the average weight of 374-380 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Remarks:
- An amount of 2.0mL of the aqueous solution of the silver nitrate was applied to a skin depot (exposure area 3.1cm2), which was subsequently covered.
- Duration of exposure:
- 5 hours
- Doses:
- 0.239 moles in 2.0 mL of aqueous solution
- No. of animals per group:
- 20 animals
- Details on study design:
- Guinea pigs were observed for symptoms, food and water intake, and number of deaths. They were weighted once a week.
Results and discussion
- Total recovery:
- After 3 weeks no animals died after exposure to silver nitrate via dermal route.
The weight of animals treated with silver nitrate increased after 1 week
Applicant's summary and conclusion
- Conclusions:
- Less than 1 % of an applied dose of silver nitrate was absorbed across intact skin of
guinea pigs within 5 hours of exposure. Test system not according to current standards
(i.e., no mass balance, no analysis of actual percutaneous transfer or residual Ag in skin
layers).
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