Registration Dossier
Registration Dossier
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EC number: 229-654-7 | CAS number: 6640-24-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: silico prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
DEREK is a knowledge-based expert system designed to apply structure-activity relationships to compounds for which little or no data exists and hence to aid in the assessment of their potential toxicity. The DEREK knowledge base contains a large number of rules that associate a chemical structure with one or more toxicity end points. When a structural alert is identified a reasoning programme assigns a probability to the expression of toxicity by the test compound. - GLP compliance:
- not specified
- Type of study:
- other: silico prediction
Test material
- Reference substance name:
- 1-(m-chlorophenyl)piperazine
- EC Number:
- 229-654-7
- EC Name:
- 1-(m-chlorophenyl)piperazine
- Cas Number:
- 6640-24-0
- Molecular formula:
- C10H13ClN2
- IUPAC Name:
- 1-(3-chlorophenyl)piperazine
Constituent 1
Results and discussion
Any other information on results incl. tables
The presence of a skin sensitization structural alert within a molecule indicates the molecule has the potential to cause skin sensitization. Whether or not the molecule will be a skin sensitizer will also depend upon its percutaneous absorption. Generally, small lipophilic molecules are more readily absorbed into the skin and are therefore more likely to cause sensitization.
plausible: the weight of evidence supports the proposition
Applicant's summary and conclusion
- Interpretation of results:
- other: plausible Alert
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- The presence of a skin sensitization structural alert within a molecule indicates the molecule has the potential to cause skin sensitization. Whether or not the molecule will be a skin sensitizer will also depend upon its percutaneous absorption. Generally, small lipophilic molecules are more readily absorbed into the skin and are therefore more likely to cause sensitization.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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