Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: in silico prediction
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(m-chlorophenyl)piperazine
EC Number:
229-654-7
EC Name:
1-(m-chlorophenyl)piperazine
Cas Number:
6640-24-0
Molecular formula:
C10H13ClN2
IUPAC Name:
1-(3-chlorophenyl)piperazine

Test animals

Species:
rabbit
Strain:
not specified

Results and discussion

Any other information on results incl. tables

Skin irritation shows an alert with an high predicted value. Generally, the piperazine derivatives in most cases exhibit rabbit skin irritating properties.

Applicant's summary and conclusion

Interpretation of results:
other: alert
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
Skin irritation shows an alert with an high predicted value. Generally, the piperazine derivatives in most cases exhibit rabbit skin irritating properties.