Registration Dossier
Registration Dossier
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EC number: 203-544-9 | CAS number: 108-03-2
Carcinogenicity
Administrative data
Description of key information
Chronic study in rats exposed via inhalation for up to 21.5 months and a sub-chronic 26 week oral gavage study in rats .
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 89.1 mg/kg bw/day
Carcinogenicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 364 mg/m³
Justification for classification or non-classification
In a sub-chronic and chronic toxicity studies in rats exposed to 1 -nitropropane there was no increased tumor incidences in male or female rats. Therefore, the carcinogenicity of 1 -nitropropane is not classifiable according to GHS.
Additional information
In a chronic toxicity study, male and female Long-Evans rats were exposed to 100 ppm (364 mg/m3) 1 -nitropropane vapor for 7 hours a day 5 days a weeks for up to 21.5 months. Upon histologic examination no hepatocarcinomas were found in the exposed group.
In a sub-chronic study, male Spraque Dawley rats were exposed to 1 mmole//kg (89.1 mg/kg) of 1 -nitropropane 3 x a week for 16 weeks then once per week for an additional 10 weeks. No treatment related tumours occurred in the rats.
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