Registration Dossier
Registration Dossier
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EC number: 203-544-9 | CAS number: 108-03-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1956-57 and 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, but sufficient data is available for interpetation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 956
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Female rats were exposed to graded doses of 1-nitropropane vapor in a closed chamber for a periods of one hour. The LC50 concentrations were determined.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-nitropropane
- EC Number:
- 203-544-9
- EC Name:
- 1-nitropropane
- Cas Number:
- 108-03-2
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- 1-nitropropane
- Details on test material:
- 1-Nitropropane :
Purity: 96.12%
Source: Sterington, Lousianna
Lot number: 9A17-7B
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Six female Wistar rats weighing 150 - 200 g.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- One hour inhalation exposures were conducted to determine the LD50 of the compound. The atmospheres were generated using a constant infusion pump and a vaporizer. The exposures occurred under dynamic airflow conditions.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Colormetric analysis
- Duration of exposure:
- 1 h
- Concentrations:
- Actual concentrations: 8.60, 11.02, and 14.40 mg/L
- No. of animals per sex per dose:
- 6 female rats per dose
- Control animals:
- not specified
- Details on study design:
- Female rats were exposed to graded doses of 1-nitropropane vapor in a closed chamber. One hour inhalation exposures were conducted to determine the LC50 of the compound. The atmospheres were generated using a constant infusion pump and a vaporizer. The exposures occurred under dynamic airflow conditions. Animals were observed 7 days following exposure.
- Statistics:
- The following endpoint was established using the Miller-Tainter method of LD50 dosage response determination.
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 11.02 mg/L air
- Exp. duration:
- 1 h
- Mortality:
- Mortality observed in animals over 7 day period following exposures to 8.6, 11.02, and 14.40 mg/L where 0, 3, and 5 animals died after one hour of exposure, respectively.
- Clinical signs:
- other: Irritation at five minutes of exposure, no convulsant action noted except at 17 mg/L were it appeared slight. Concentration of 1-nitropropane was not sufficient for anesthetic effects. All animals exhibited ataxia following removal from the chamber. N
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
The acute inhalation toxicity, the LC50 was calculated from a rat LC50 at 1 hr (11.02 mg/L) by dividing by 2 as per the following guideline, "NFPA, Recommendations on the Transport of Dangerous Goods, UN Publication, 4th Ed. Section 6.4)." The calculated LC50 value of 5.5 mg/L was converted to 5500 mg/m3.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- Following a 1 hour inhalation exposure, the LC50 is 11.02 mg/l .
- Executive summary:
None
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