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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
other: draft guidance document EUR 20268 (20029, part 5.2 “Laser scattering /diffraction” for “Particle Size Distribution, Fibre Length and Diameter Distribution”, European Commission, Directorate General JRC)
Deviations:
no
Principles of method if other than guideline:
Laser granulometry is a measuring technique used to analyse particle size in powders, granulates, suspensions and emulsions, based in the principle of diffraction (= scattering) of a bundled laser beam.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
- Name of test material (as cited in study report):Pigment Red 52 Strontium Salt
- Analytical purity: 94.3%
- Physical state: powder
- Lot/batch No.: HW-08-011
- Expiration date of the lot/batch: January 01, 2017
Key result
Percentile:
D50
Mean:
27.38 µm
Remarks on result:
other: average value of three measurements
Key result
Percentile:
D10
Mean:
4.09 µm
Remarks on result:
other: average value of three measurements
Key result
Percentile:
D90
Mean:
517.28 µm
Remarks on result:
other: average value of three measurements
Conclusions:
The particle size distribution of test substance was determined to be MMD= 27.4 µm

Description of key information

Dry dispersion:

MMD =27 µm

D10= 4 µm

D90= 517 µm

Additional information

The determination was carried out by laser diffraction method. The measurement of the dry powder was chosen as the key study.