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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please see the category read-across justification in the category object.
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across: supporting information
Key result
Conc. / dose:
0.03 mg/L
Type:
BCF
Value:
< 6.9 L/kg
Time of plateau:
42 d

Description of key information

Accumulation in organisms is not to be expected. 

Key value for chemical safety assessment

Additional information

Two studies, conducted with two analogues of the category (CAS 5281-04-9 and CAS 73612-29-0), were performed according to OECD 305. Fish (Cyprinus carpio) were exposed to CAS 5281-04-9 in concentrations of 0.3 mg/L and 0.03 mg/L, respectively. The test was terminated after 6 weeks of exposure. At a substance concentrations of 0.3 mg/L a BCF of 0.7 - 1.8 was determined. At a concentration of 0.03 mg test substance/L a BCF < 6.9 was detected (JETOC, 1992).

In a second study, fish (Cyprinus carpio) were exposed to CAS 73612-29-0 in concentrations of 0.1 mg/L and 0.01 mg/L, respectively (Dainippon Ink and Chemicals Inc. 2006). The test was terminated after 28 days of exposure. At a substance concentrations of 0.1 mg/L a BCF of <= 4.4 was determined. At a concentration of 0.01 mg test substance/L a BCF <= 0.44 was detected. Even though only limited information is available of this study, the result can be used to support the overall conclusion in a weight of evidence approach.

Furthermore, in a third study, Cyprinus carpio was exposed to CAS 15782 -05 -5 in concentrations of 0.1 and 0.01 mg/L, respectively (NITE 1996). After 6 weeks of exposure a BCF value af 0.4 - 1 L/kg was determined for the test concentration of 0.1 mg/L. For the second test concentration of 0.01 mg/L a BCF value of <= 0.4 L/kg was determined. Also for this study only limited information is available. Nevertheless, the results support the overall conclusion as well.

Overall, the category is assessed to not significantly accumulate in organisms. Furthermore, no bioaccumulation is expected as each of the category members have log Kow values <3.