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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from October 18, 2007 to November, 10, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
yes
Remarks:
stock solution was prepared in water pre-saturated with n-octanol
Principles of method if other than guideline:
- Short description of test conditions: A stock solution of the test substance should be prepared in n-octanol pre-saturated with water. Because of low solubility of the test substance in this medium, the stock solution was prepared in water pre-saturated with n-octanol. This deviation has no effect on the determination of log Pow of the test substance.
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Key result
Type:
log Pow
Partition coefficient:
ca. -2.08
Temp.:
23 °C
pH:
9.5
Details on results:
Standard extended uncertainty 0.44.


Conclusions:
Partition coefficient (log P) of the test substance - Humic acids, sodium salts - determined by shake-flask method is:
log Pow = -2.08 ± 0.44 (pH = 9.5, 23ºC)

The partition coefficient shows some suggestion of concentration dependency.
Executive summary:

The partition coefficient of the test substance was determined. The shake-flask method was used.

The test was performed according to the Method A.8, Partition coefficient, Directive 92/69/EEC, Published in OJ No L 383A, 1992.

Description of key information

hod A.8, Partition coefficient, Directive 92/69/EEC, Published in OJ No L 383 A, 1992.
GLP study.

is:

log Pow = -2.08 ± 0.44 (pH = 9.5, 23ºC)

The partition coefficient of the test substance was determined. The shake-flask method was used.

The test was performed according to the Method A.8, Partition coefficient, Directive 92/69/EEC, Published in OJ No L 383A, 1992.

Partition coefficient (log P) of the test substance - Humic acids, sodium salts - determined by shake-flask method is: log Pow = -2.08 ± 0.44 (pH = 9.5, 23ºC)

The partition coefficient shows some suggestion of concentration dependency.

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.08
at the temperature of:
20 °C

Additional information

The partition coefficient of the test substance was determined. The shake-flask method was used.

The test was performed according to the Method A.8, Partition coefficient, Directive 92/69/EEC, Published in OJ No L 383A, 1992.

Partition coefficient (log P) of the test substance - Humic acids, sodium salts - determined by shake-flask method is:

log Pow = -2.08 ± 0.44 (pH = 9.5, 23ºC)

The partition coefficient shows some suggestion of concentration dependency.