Registration Dossier
Registration Dossier
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EC number: 236-537-4 | CAS number: 13423-15-9
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
May not readily biodegrade, but is expected to be inherently biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
No reliable screening tests on the biodegradation of Tetrahydro-3-methylfuran are available but biodegradation can nonetheless be reliably predicted by QSAR modeling and read-across to a closely related substance, Tetrahydrofuran (CAS# 109-99-9). The estimate of biodegradability calculated using BioWin v. 4.10 predicts that Tetrahydro-3-methylfuran is readily biodegradable (BioWin v4.10 2010). However, this same prediction is made by BioWin v. 4.10 for Tetrahydrofuran (CAS# 109-99-9) but is not supported by an OECD 301d guideline study of Tetrahydrofuran (CAS# 109-99-9) which concluded, based on oxygen consumption, that the substance is not readily biodegradable showing only 39% degradation after 28 days but is expected to be inherently biodegradable after prolonged exposure (Van Ginkel, 1992). In addition, THF degraded 100% in 14 days based on oxygen consumption in an OECD 302d Inherent Biodegradability guideline study (NITE, 2002) and thus was considered inherently biodegradable. In the absence of reliable data to the contrary and despite the QSAR model prediction, Tetrahydro-3-methylfuran should therefore also be regarded as inherently biodegradable rather than readily biodegradable.
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