Octanoic acid, zinc salt, basic

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: Acc. DGF-Einheitsmethode, H-II 2 (65)

GLP compliance:

no

Type of method:

sieving

Type of distribution:

mass based distribution

Remarks on result:

not measured/tested

Percentile:

D10

Mean:

175 µm

Remarks on result:

other: standard deviation not stated

Percentile:

D50

Mean:

315 µm

Remarks on result:

other: standard deviation not stated

Percentile:

D90

Mean:

470 µm

Remarks on result:

other: standard deviation not stated

	Measurement
> 1000 µm	1.23 %
> 800 µm	1.14 %
> 500 µm	17.14 %
> 400 µm	33.34 %
> 300 µm	32.86 %
> 200 µm	10.24 %
> 100 µm	3.32 %
> 63 µm	0.13 %
< 63 µm	0.00 %

Median diameter
D 10%	175 µm
D 50%	315 µm
D 90%	470 µm

Conclusions:

The D10, D50 and D90 of the PSD of octanoic acid, zinc salt, basic (i.e., Stabiol ZN 1950, batch 11 K 5703) are 175 µm, 315 µm, and 470 µm, respectively.

Reference 2

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

DIN 55992-1 (Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method)

Version / remarks:

2006

Deviations:

yes

Remarks:

Heubach dust meter is modified by using 7 stage cascade impactor connected to the system. This involves an add. air fed of 20 L/min via coarse dust separator to supply the impactor with 40 L/min air current as specified in manufacturer’s specifications.

GLP compliance:

no

Type of method:

cascade impaction

Type of distribution:

volumetric distribution

Mass median aerodynamic diameter:

32.58 µm

Geometric standard deviation:

1.52

Percentile:

D50

Remarks on result:

not measured/tested

Dustiness (airborne fraction): total: 55.23 mg/g.

In the original study report by DMT, a calculation of the mass median diameter was not conducted. Since the deposited fractions were provided for each of the cascade impactor stages, it was possible to fit a mono modal lognormal distribution to the databy standard non-linear regression procedure. As a result, the MMAD and GSD of total dustiness (airborne) fraction are calculable and reported (MMAD = 32.58 µm, GSD = 1.52). As the cascade impactor already takes aerodynamic characteristics of the particles into account, the reported mass median diameter can be interpreted as the mass medianaerodynamicdiameter.

This figure and the corresponding GSD were used as distribution parameters for the MPPD model enabling an estimation of deposited dust fractions in the human respiratory tract: These fractions were estimated as follows:

Head (ET): 40.3%

Tracheobronchial (TB): 0.0%

Pulmonary (PU): 0.0%

Conclusions:

Total Dustiness (airborne fraction): 55.23 mg/g (experimental results, DMT Report).

Mass median aerodynamic diamater of total dustiness (airborn) fraction: MMAD = 32.58 µm (distribution fitted to cascade impactor data).
Geometric standard deviation of MMAD: GSD = 1.52

Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 40.3 %
Tracheobronchial (TB): 0.0 %
Pulmonary (PU): 0.0 %

Description of key information

The granulometry of a representative sample of Octanoic acid, zinc salt, basic is:

Particle size Distribution (Hernandez Blanco, 2011-2012)

- D10: 175 µm

- D50: 315 µm

- D90: 470 µm

Dustiness (Parr, Grewe, 2012):

-Total Dustiness (airborne fraction): 55.23 mg/g

- MMAD = 32.58 µm (distribution fitted to cascade impactor data).

-  GSD = 1.52

- Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):

Head (ET): 40.3 %

Tracheobronchial (TB): 0.0 %

Pulmonary (PU): 0.0 %

Additional information

Particle size Distribution (Hernandez Blanco, 2011-2012)

The D10, D50 and D90 of the PSD of octanoic acid, zinc salt, basic (i.e., Stabiol ZN 1950, batch 11 K 5703) are 175 µm, 315 µm, and 470 µm, respectively.

Dustiness (Parr, Grewe, 2012)

Total Dustiness (airborne fraction): 55.23 mg/g (experimental results, DMT Report).

Mass median aerodynamic diameter of airborne fraction: MMAD = 32.58 µm (distribution fitted to cascade impactor data).

Geometric standard deviation of MMAD: GSD = 1.52

Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):

Head (ET): 40.3 %

Tracheobronchial (TB): 0.0 %

Pulmonary (PU): 0.0 %