Registration Dossier
Registration Dossier
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EC number: 213-986-4 | CAS number: 1071-22-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature (IUCLID 2000 data set). The original reference was not available for review and no further information is available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-(trichlorosilyl)propiononitrile
- EC Number:
- 213-986-4
- EC Name:
- 3-(trichlorosilyl)propiononitrile
- Cas Number:
- 1071-22-3
- Molecular formula:
- C3H4Cl3NSi
- IUPAC Name:
- 3-(trichlorosilyl)propanenitrile
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Concentration: 5 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- No data
- Number of animals:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: overall result
- Remarks on result:
- other: 5 mg caused severe irritancy
Applicant's summary and conclusion
- Conclusions:
- In a very limited summary of an skin irritation study in IUCLID 2000 (reliaility score 4), 5 mg of 3-(trichlorosilyl)propiononitrile caused severe irritation in rabbits.
- Executive summary:
In a very limited summary of an skin irritation study in IUCLID 2000 (reliaility score 4), 5 mg of 3-(trichlorosilyl)propiononitrile caused severe irritation in rabbits. No further details available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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