Registration Dossier
Registration Dossier
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EC number: 201-055-5 | CAS number: 77-75-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methylpentynol
- EC Number:
- 201-055-5
- EC Name:
- Methylpentynol
- Cas Number:
- 77-75-8
- Molecular formula:
- C6H10O
- IUPAC Name:
- 3-methylpent-1-yn-3-ol
- Details on test material:
- purity 99.9%, undiluted
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of the undiluted test substance
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 2 male, 1 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Executive summary:
The skin irritating potential of methylpentynol was assessed in an OECD 404 guideline study. Three White Vienna rabbits receiced 0.5 mL undiluted test substance on the shaved skin. The exposure duration was 4 h under semiocclusive conditions (then washing off). The skin reactions were examined 4, 24, 48 & 72 h post treatment. The mean scores of erythema and edema were 0.1 and 0 in three rabbits 24, 48 and 72 h after application. The observed effects were fully reversible within 72 hours. Based on these findings methylpentynol is considered to be non irritating to the rabbit skin.
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