Registration Dossier
Registration Dossier
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EC number: 929-889-1 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 11 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 6.2
- Details on results:
- Result of the preliminary test: 9 mg/L
- Conclusions:
- The water solubility of 11 mg/L was measured at 20 °C and pH 6.2 for the test substance.
- Executive summary:
The study was performed according to guideline A.6 for determination of water solubility, EG-guideline 92/69. In a preliminary test the water solubility was determined as 9 mg/L. Therefore, the shake flask method was executed. The test substance was weighted in three flasks and solved in water. The solutions were agitated for 24, 48 and 72 h at 30°C in and afterwards for 24 h at 20 °C. The test concentration was determined by HPLC-analysis. A water solubility of 11 mg/L was measured (mean value from 3 single values).
Reference
Description of key information
The study was performed according to guideline A.6 for determination of water solubility, EG-guideline 92/69. In a preliminary test the water solubility was determined as 9 mg/L. Therefore, the shake flask method was executed. The test substance was weighted in three flasks and solved in water. The solutions were agitated for 24, 48 and 72 h at 30°C in and afterwards for 24 h at 20 °C. The test concentration was determined by HPLC-analysis. A water solubility of 11 mg/L was measured (mean value from 3 single values).
Key value for chemical safety assessment
- Water solubility:
- 11 mg/L
- at the temperature of:
- 20 °C
Additional information
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