Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June-November 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study done according to the respective OECD guideline under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
yes
Type of method:
other: differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Nadide
EC Number:
200-184-4
EC Name:
Nadide
Cas Number:
53-84-9
Molecular formula:
C21H27N7O14P2
IUPAC Name:
nadide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Substance type: organic
- Physical state: off-white powder
- Storage condition of test material: in refrigerator (2-8°C)

Results and discussion

Melting / freezing point
Remarks on result:
other: reaction and/or decomposition of the substance was observed starting at 150°C. Melting point was not observed below which reaction and/or decomposition of the substance started. the test substance has no melting point

Applicant's summary and conclusion

Conclusions:
Reaction and/or decomposition of the test substance was observed starting at 150°C (423K). Melting and/or boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test substance has no melting and/or boiling
temperature.
Executive summary:

The melting temperature of the test substance were determined using differential scanning calorimetry (DSC) acc. to OECD guideline 102. The melting temperature is defined as the temperature at which the phase transition from solid to liquid state takes place at normal atmospheric pressure. This temperature ideally corresponds to the solidification or freezing temperature.

In the Preliminary test 2.55 mg test substance was heated with a rate of 20°C/minute from 25°C to 550°C. At this point 48% weight loss of the test substance was observed. After the experiment, the sample was cooled to 50°C and the consistency of the test substance was determined.

In the main study an endothermic peak between 75°C and 150°C was observed. The effect was most likely obtained due to evaporation of some water vapour from the test substance. An exothermic effect was seen between 150°C and 225°C. This effect is most likely due to reaction and/or decomposition of the test substance. No melting and/or boiling point could be observed. After the experiment, a black charred residue remained in the sample container.