Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only very little information is available. The information is based on an internal memorandum with a short summary of the results of a study report. The full study report is not available.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
The test substance is the racemate 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 69335-91-7). It is a 1:1 mixture of the two enantiomers (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 83066-88-0; the substance defined in section 1) and (2S)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 95977-30-3).

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
other: test substance (racemate)
Other findings:
A slight irritant effect was observed during the course of the experiment.

Any other information on results incl. tables

Full information as given in the memorandum:

Acute dermal LD50 (rats) 5000 mg/kg

A slight irritant effect was observed during the course of the experiment.

Applicant's summary and conclusion