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Dissociation constant

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Description of key information

2.98, 20°C, potentiometric method, OECD 112, Wollerton 
3.22(±0.03), 25±1°C, titration method, OECD 112, Chamberlain

Key value for chemical safety assessment

pKa at 20°C:

Additional information

Two experimental values are available for 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid. One is for the R-enantiomer (Wollerton), the second is for the racemate (Chamberlain); both are equivalent for this endpoint. While both reported values are in reasonable agreement, those from Wollerton are selected to maintain dataset consistency, and as they were collected under GLP. However, it is likely those reported by Chamberlain are the more accurate.