Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

EC10 (3 h) > 1000 mg/l (nominal), EC50 (3h) > 1000 mg/l (nominal). No effects occur in the range of water solubility and well above the water solubility.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
1 000 mg/L

Additional information

Since no study for assessing the toxicity to aquatic microorganisms of 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2) is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Didodecyl fumarate (CAS 2402-58-6, MW 453 g/mol), Ditetradecyl fumarate (CAS 10341-03-4, MW 509 g/mol) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9, MW 621-733 g/mol) was conducted. 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2) exhibits a molecular weight range of 340.5 - 621 g/mol. Thus, the read across is covered by interpolation for this substance. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile.

Further justification is given within the endpoint summary 6.1 and within the category justification section 13.

 

Activated sludge respiration inhibition tests conducted according to OECD 209 are available for the PFAE fumarates category members Ditetradecyl fumarate (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9). No effects were observed in concentrations well above the limit of water solubility. In addition, an oxygen consumption test according to a German national guideline (DIN 38412, part 27) is available for Didodecyl fumarate (CAS 2402-58-6), showing no effects on Pseudomonas putida as well (Kirch, 1995).

Due to the structural and physico-chemical property similarities with the tested category members Didodecyl fumarate (CAS 2402-58-6), Ditetradecyl fumarate (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18- 22- alkyl esters (CAS 68921-53-9), this result is also applicable to read across to 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2).

The results of all three studies show distinctly, that no effects occur in the range of water solubility and well above the water solubility (i.e. EC50 > 1000 mg/l in all tests). Therefore, disturbances in sewage treatment plants are not anticipated for the members of the PFAE fumarates category.