Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 271-239-8 | CAS number: 68526-91-0 A complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isotridecanal from the hydroformylation of dodecene. It consists predominantly of C13-14 primary aliphatic alcohols, C22-28 dimer alcohols, C26 acetals and esters, and C>10 acid sodium salts and boils in the range of approximately 250°C to 450°C (482°F to 842°F).
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecene, hydroformylation products, high-boiling
- EC Number:
- 271-239-8
- EC Name:
- Dodecene, hydroformylation products, high-boiling
- Cas Number:
- 68526-91-0
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction products of dodecene, hydroformylation products, high boiling
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 13
- Physical state: liquid, clear
- Composition of test material: mixture of C13-alcohols, C13-acids and -esters
- Stability under test conditions: yes
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH
- Age at study initiation: ca. 12 weeks
- Weight at study initiation: mean males: 170 g; mean females: 170 g
- Fasting period before study: 16 hrs (water ad libitum)
- Housing: 5 animals per cage
- Diet: Ssniff R
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26
- Humidity (%): 45-75
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% Carboxymethylcellulose
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: according to physiological conditions
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: - weighing on day 2, day 7 and day 13; - frequency of observations: < 15 min, 15 min, 30 min, 1 hr, 2 hrs, 4 hrs, 5 hrs after substance administration; 2 times daily (working days), once daily (public holidays): check on moribund and dead animals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - no mortality observed
- Clinical signs:
- other: - no clinical signs observed
- Gross pathology:
- - no abnormalities observed
- Other findings:
- - Histopathology: no abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Oxooel 13 is practically non-toxic after oral administration.
- Executive summary:
The study is conducted according to OECD 401. Groups of 5 rats per sex and dose were administered 5000 mg/kg bw of the test substance. No mortality, no clinical signs and no pathological abnormalities were observed.
Conclusion:
Oxooel 13 is practically non-toxic after oral administration.
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