Nonanedioic acid, 1,9-bis(2-octyldodecyl) ester

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short summary available

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth, H.F. Jr. et al.

Year:

1962

Bibliographic source:

Amer Ind Hyg Assoc J 23:95-107

Reference 2

Reference Type:

secondary source

Title:

Bis(2-ethylhexyl) azelate

Author:

OECD

Year:

2006

Bibliographic source:

SIDS Initial Assessment Report for SIAM 22, Paris, France, 18-21 April, 2006

Materials and methods

Principles of method if other than guideline:

Primary skin irritation on rabbits was determined on clipped skin after application of the test item or test item solution for 24 h with a 10-grade scale.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-ethylhexyl) azelate

EC Number:

203-091-7

EC Name:

Bis(2-ethylhexyl) azelate

Cas Number:

103-24-2

Molecular formula:

C25H48O4

IUPAC Name:

bis(2-ethylhexyl) azelate

Details on test material:

- Name of test material (as cited in study report): Azelaic acid, di-(2-ethylhexyl) ester
- Analytical purity: no data

Test animals

Species:

rabbit

Strain:

other: albino

Test system

Type of coverage:

open

Preparation of test site:

other: clipped

Vehicle:

other: unchanged (no vehicle) and vehicle (water, propylene glycol or acetone) for testing solutions

Controls:

other: not required, untreated sites of the same animal served as control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 mL
- Concentration: 100% or 0.01% solution

Duration of treatment / exposure:

24 hours

Observation period:

no data

Number of animals:

5

Details on study design:

SCORING SYSTEM:
A 10-grade scoring system was used. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.

Results and discussion

In vivo

Results

Irritation parameter:

other: grade of irritation

Basis:

mean

Remarks:

of all 5 animals

Time point:

other: no data

Score:

3

Max. score:

10

Reversibility:

no data

Remarks on result:

other: The exposure duration was 24 h. The scoring time point is not given.

Any other information on results incl. tables

The test substance had a grade of 3 according to the scoring system, which was applied within this study. However, it is not possible to ransfer these grading scores into Draize scores as required according to OECD guideline 404.