Registration Dossier
Registration Dossier
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EC number: 618-295-5 | CAS number: 897626-46-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 0.004 mg/L in aqua dest) for Daphnia magna (OECD 211)
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity of Bis(2-octyldodecyl) azelate (CAS 897626-46-9) to aquatic invertebrates are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member Bis(2-ethylhexyl) azelate (CAS 103-24-2) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
Long term toxicity of Bis(2-ethylhexyl) azelate was investigated by the Japanese authorities according to OECD 211 under semi static conditions using Daphnia magna as a test organism (MOE, 2004). A 0.1 mg/L test solution was prepared by diluting a 1000 mg/L stock solution prepared using HCO-40 as vehicle. The test concentration was measured to be 0.0637 mg/L. No effects on parent animal mortality and reproduction were observed throughout the 21 d test period of the limit test. Hence, the 21 d-NOEC is determined to be > 0.0637 mg/L which is the water solubility of the test substance under test conditions.
Due to the structural and property similarities with the tested category member Bis(2 ethylhexyl) azelate (CAS 103-24-2) this result is also applicable to read across to Bis(2-octyldodecyl) azelate (CAS 897626-46-9).
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