Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-470-3 | CAS number: 646-24-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
There are no data on the toxicokinetics of NMDA. The following summary has therefore been prepared based on validated predictions of the physicochemical and toxicological properties of the substance itself and its known isomers. Evidence of the behaviour of the substance in vivo from the available toxicological studies in mammals has also been taken into consideration.
NMDA is a solid of low volatility. It is water miscible and forms strongly caustic solutions with pH of >12 at above 2 g/L concentration. Due to a purely industrial use of this substance exposure may occur via the inhalation or dermal routes. Oral exposure of man via the environment must not be considered due to the biodegradability of the substance.
Absorption
The low vapour pressure and the low dustiness of the substance favour dermal absorption. However, the very high water solubility (1E+06 mg/L) and low predicted log Kow(1.82) suggest that it is too hydrophilic to cross the lipid rich stratum corneum. Since this substance is corrosive to the skin, damage to the skin might increase penetration. Acute dermal toxicity studies are not available and therefore a worst case dermal absorption of 100% has been assumed for the risk assessment.
The partition coefficient value for the substance indicates that it is likely to be absorbed directly across the respiratory tract epithelium by passive diffusion. Inhalation absorption was taken as 100%.
Due to the water solubility the substance is likely to be readily absorbed after oral exposure. An absorption factor of 100% is taken as worst case.
Distribution
The hydrophilic nature of the substance will limit its diffusion across membranes (including the blood-brain and blood-testes barriers) and its accumulation in fatty tissue.
Metabolism
There are no studies of metabolic pathways of NMDA. Genetic toxicity tests in vitro of the similar substance MODA (CAS 148528-05-6) showed no significant (2-fold or greater) differences in effects with and without metabolic activation.
The following metabolites are expected to appear from investigations of similar diamines (e.g. published data on hexamethylene diamine (CAS 124-09-4): Oxidation of one amine group leads to 9-aminononanoic acid which is likely to be one metabolite. Also acetylated amines are common and are expected in NMDA metabolism.
Excretion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
