Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-515-7 | CAS number: 1236007-63-8
Endpoint summary
Administrative data
Description of key information
Acute toxicity data are available from longer-term repeated dose studies conducted on both isomaltulose greens and isomaltulose. In both studies doses higher than the standard acute toxicity limit dose were given orally by gavage daily for 26 weeks. No acute toxicity signs were observed in either study, demonstrating that isomaltulose greens are not acute toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 500 mg/kg bw
Additional information
Toxicity tests was conducted in which isomaltulose greens or isomaltulose were administered to male and female rats for 26 weeks. Doses (1,500, 3,000 and 4,500 mg/kg) were administered orally via gavage once a day. Random deaths attributable to perforation of the esophagus due to administration failure were observed but were not treatment related. No other mortalities were observed. Since the doses were well above the usual acute toxicity test limit dose, and no mortality or marked clinical signs were observed, the studies demonstrate the lack of acute toxicity.
Justification for classification or non-classification
Isomaltulose greens is not toxic at oral doses up to and including 4,500 mg/kg, therefore isomaltulose greens is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
