Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other:
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review paper that summarizes the metabolism of isomaltulose, the main component of isomaltulose greens along with trehalulose.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2002

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
The study reviewed the metabolism of isomaltulose as documented in other studies.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Isomaltulose is a structural isomer of sucrose and the main component of isomaltulose greens along with another isomer, trehalulose.

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

Isomaltulose, a main component of isomaltulose greens and a structural isomer of sucrose, is hydrolyzed slowly in the intestinal tracts of mammals, though metabolism may be more rapid in rats and dogs than humans. In humans, isomaltulose is largely and rapidly excreted in the urine unchanged. The other main component of isomaltulose greens, trehalulose, is also a structural isomer of sucrose and thus would have the same metabolic characteristics as isomaltulose.