Registration Dossier
Registration Dossier
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EC number: 306-060-7 | CAS number: 95873-69-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
- EC Number:
- 306-060-7
- EC Name:
- Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
- Cas Number:
- 95873-69-1
- Molecular formula:
- C12H10O6.Na
- IUPAC Name:
- sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch 44034
Description: Cream to light grey powder
Expiry date: 30 November 2019
Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%).
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 25 °C
- pH:
- >= 7 - <= 9
Any other information on results incl. tables
The three calibration series and three test item series were measured. The partition coefficient Powwas determined based on a calibration curve using 6 reference substances.
The capacity factors k were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Powvalues.
The equation of the curve fitted to the calibration points is as follows:
log Pow= 2.53 × log k + 1.89 (r2= 0.937)
Applicant's summary and conclusion
- Conclusions:
- The estimated log Pow is < 1.0.
- Executive summary:
In the course of this study the partition coefficient (log Pow) of Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate was estimated using high performance liquid chromatography.
The estimated log Powis < 1.0.
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