Registration Dossier
Registration Dossier
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EC number: 258-946-7 | CAS number: 54060-92-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The available data on the acute toxicity to fish are used in a weight-of-evidence approach. The 96-h LC50 of 3.14 mg/L for Danio rerio is used as key value in the chemical safety assessment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.14 mg/L
Additional information
In 1979, the 96-h LC50 for the acute toxicity of the test item to Golden orfe (Leuciscus idus) was determined to be in the range of 10 to 100 mg/L (LC0 = 10 mg/L, LC100 = 100 mg/L; see Markert 1979 & Markert 1979b). In these two studies the dyestuff concentration is reported to be 22%. Sodium sulphate comprised 77 % of the substance composition. As the LC50 for sodium sulphate to fish is ca. 8000 mg/L (see ECHA dissemination page), it can reasonably be assumed that the toxic effects observed in these two studies were related to the dyestuff. The 96-h LC50 for the test item is equivalent to a 96 -h LC50 of 2.2-22 mg a.i./L for the dyestuff.
In an additional study with Leuciscus idus (Munk, 1987), the 96-h LC50 was determined to be 87 mg/L. The acute toxicity towards Danio rerio as determined in 1986 is LC50 = 70.1 mg/L. However, no information on the respective dyestuff concentration of the test item is available from these two studies. Furthermore, the full study report for the test conducted with Danio rerio is not available, and the information was available from a secondary source only.
The 96-h LC50 of the test item to Danio rerio reported in 1989 (secondary source) is 3.14 mg/L. As raw, dry test material was used in the test, a high test substance concentration is assumed.
The available data is used in a weight-of evidence approach. Based on a reasonable range of the 96-h LC50 of 2.2-22 mg/L reported in sufficiently reliable studies, and the indication for Danio rerio being slightly more sensitive compared to Leuciscus idus, the 96-h LC50 of 3.14 mg/L is used as key value in the chemical safety assessment.
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