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EC number: 258-946-7
CAS number: 54060-92-3
*= 1st number: number of dead animals, 2nd number: number of animals
with clinical symptoms,
3rd number: number of animals
Mass Median Aerodynamic Diameter (MMAD): 1.69 µm
Geometric standard deviation: 1.83
Respirability (% < 3 µm):
a) mass related: 83 % (measured)
b) number related: 100 % (extrapolated)
Mass Median Aerodynamic Diameter (MMAD): 3.21 µm
Geometric standard deviation: 2.24
a) mass related: 47 % (measured)
Mass Median Aerodynamic Diameter (MMAD): 3.20 µm
Geometric standard deviation: 2.12
b) number related: 99 % (extrapolated)
Mass Median Aerodynamic Diameter (MMAD): 1.96 µm
Geometric standard deviation: 1.81
a) mass related: 77% (measured)
Mass Median Aerodynamic Diameter (MMAD): 4.18 µm
Geometric standard deviation: 2.11
a) mass related: 33% (measured)
b) number related: 97 % (extrapolated)
In an acute inhalation toxicity study equivalent to OECD 403, groups of
young adult male and female Wistar rats (5 per sex/concentration) were
exposed by the inhalation route (nose/head only) to the test item for 4
hours at mean concentrations of 0, 9, 51, 75, 167 and 388 mg/m³ air.
Animals then were observed for 14 days. Mortality and distinct clinical
signs were observed after exposure to the test substance at 51 mg/m³ air
and higher. No mortality and no signs of toxicity occured after
inhalation to 9 mg/m³. Based on the results obtained, the LC50 for both
sexes is 76 mg/m³ air.
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