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Diss Factsheets

Environmental fate & pathways

Adsorption / desorption

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Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR model
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
1.811
Temp.:
25 °C
Remarks on result:
other: based on Kow method
Type:
Koc
Value:
64.7
Temp.:
25 °C
Remarks on result:
other: based on Kow method

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR model
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
2.004
Temp.:
25 °C
Remarks on result:
other: based on MCI
Type:
Koc
Value:
100.8
Temp.:
25 °C
Remarks on result:
other: based on MCI

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Validated QSAR model. Calculation for hydrolysis product of Methacryloyloxyethyl isocyanate. Data for the hydrolysis products are given as the parental compound gets rapidly hydrolyzed in the aquatic environment to form the more stable hydrolysis products.
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
1
Temp.:
25 °C
Remarks on result:
other: based on Kow method
Type:
Koc
Value:
10.08
Temp.:
25 °C
Remarks on result:
other: based on Kow method

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Validated QSAR model. Calculation for hydrolysis product of Methacryloyloxyethyl isocyanate. Data for the hydrolysis products are given as the parental compound gets rapidly hydrolyzed in the aquatic environment to form the more stable hydrolysis products.
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
1.27
Temp.:
25 °C
Remarks on result:
other: based on MCI
Type:
Koc
Value:
18.6
Temp.:
25 °C
Remarks on result:
other: based on MCI

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Validated QSAR model. Calculation for hydrolysis product of Methacryloyloxyethyl isocyanate. Data for the hydrolysis products are given as the parental compound gets rapidly hydrolyzed in the aquatic environment to form the more stable hydrolysis products.
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
1.43
Temp.:
25 °C
Remarks on result:
other: based on Kow method
Type:
Koc
Value:
26.67
Temp.:
25 °C
Remarks on result:
other: based on Kow method

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption, other
Remarks:
adsorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Validated QSAR model. Calculation for hydrolysis product of Methacryloyloxyethyl isocyanate. Data for the hydrolysis products are given as the parental compound gets rapidly hydrolyzed in the aquatic environment to form the more stable hydrolysis products.
Principles of method if other than guideline:
Calculation based on KOCWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no
Type of method:
other: calculation
Media:
soil
Type:
log Koc
Value:
1.44
Temp.:
25 °C
Remarks on result:
other: based on MCI
Type:
Koc
Value:
27.94
Temp.:
25 °C
Remarks on result:
other: based on MCI

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Endpoint:
adsorption / desorption: screening
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter

Description of key information

Low adsorption potential expected due to log Kow < 3

Key value for chemical safety assessment

Additional information

According to column 2 of EC 1907/2006 Annex VIII the testing on “Adsoption/Desorption” does not need to be conducted if the substance has a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient) or if the substance and its degradation products decompose rapidly. Based on log Kow ≤ 3 for 2-isocyanatoethyl methacrylate and its degradation products the potential for adsorption is quite low. Hence, testing of the adsorption and desorption attributes is not necessary.

However, to estimate PNEC sediment and PNECsoil by the equilibrium partitioning method data of the sorption behavior of 2-isocyanatoethyl methacrylate and its degradation products were calculated. Since measured sorption values are not available for the test substance or its degradation products, the Koc was calculated using the QSAR KOCWIN v.2.00 (Hopp, 2012). For 2-isocyanatoethyl methacrylate the Koc-values determined are 100.8 L/kg based on MCI method and 64.7 L/kg based on log Kow method. The corresponding log Koc –values are 2.00 based on MCI method and 1.81 based on log Kow method.

For the degradation products, the obtained Koc-values are 27.94 L/kg for the urea dimer and 18.6 L/kg for 2-aminoethyl methacrylate based on the MCI method and 26.67 L/kg for the urea dimer to 10.08 L/kg for 2-aminoethyl methacrylate based log Kow method. The corresponding log Koc-values are 1.44 for urea dimer and 1.27 for 2-aminoethyl methacrylate based on the MCI method, and 1.43 for the urea dimer and 1.0 for 2-aminoethyl methacrylate based log Kow method.