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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification.zinc concentrations in test however not measured.
Qualifier:
according to guideline
Guideline:
other: American Society for testing matrials 1988: Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians, ASTM, E-729-88, Philadelphia
GLP compliance:
not specified
Analytical monitoring:
no
Details on sampling:
no data
Vehicle:
no
Details on test solutions:
standard reconstituted soft water (EPA 1975)
Test organisms (species):
other: Thymallus arcticus
Details on test organisms:
organisms from different origin were tested: they were from a) Clear state hatchery, Clear, Alaska, US (= code AC), and from Flathead lake salmon state hatchery, Somers, montana, US (code MT)
Test type:
static
Water media type:
freshwater
Limit test:
no
Hardness:
41 mg CaCO3/l
Test temperature:
12 +/-1°C
pH:
7.1-8.0
Nominal and measured concentrations:
no details given, nominal concentrations reported
Details on test conditions:
different life stages were tested
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
315 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 234-424; test on "swim-up fry", origin AC
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
142 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I.114-178; test on 7-8w old juveniles, 0.2g, code AC
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
112 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I. 83-150; test on 7-8w old juveniles, 0.34g, code AC
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 580 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I. 900-2770; test on alevins; code MT
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
166 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I. 127-217; test on 5-6w old juveniles, 0,97 g, code MT
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2 920 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I. 2510-3400; test on alevins; code MT
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
168 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I. 143-197; test on 7-11w old juveniles, 0.97g, code MT
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
168 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I. 96-295; test on 7-11w old juveniles, 1.85g, code MT
Reported statistics and error estimates:
The method of Litchfield and Wilcoxon was used to calculate the LC50 values and 95%C.I.
signnificant differences between LC50 values were determined by the standard error of the differences as described by Sprague and Fogels 1977.
Validity criteria fulfilled:
yes
Conclusions:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity.
Executive summary:

Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification. LC50 values: see “results” section.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification.zinc concentrations in test however not measured.
Qualifier:
according to guideline
Guideline:
other: American Society for testing matrials 1988: Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians, ASTM, E-729-88, Philadelphia
GLP compliance:
not specified
Analytical monitoring:
no
Details on sampling:
no data
Vehicle:
no
Details on test solutions:
standard reconstituted soft water (EPA 1975)
Test organisms (species):
Oncorhynchus kisutch
Details on test organisms:
organisms from different origin were tested: they were from a) Clear state hatchery, Clear, Alaska, US (= code AK), and from Puyallup Salmon hatchery, Orting, Washington, US (code WA)
Test type:
static
Water media type:
freshwater
Limit test:
no
Hardness:
41 mg CaCO3/l
Test temperature:
12 +/-1°C
pH:
7.1-8.0
Nominal and measured concentrations:
no details given, nominal concentrations reported
Details on test conditions:
different life stages were tested
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
820 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 610-1130; test on7-8w old juveniles, 0.47g, origin AK
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 810 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 1340-2450; test on7-8w old juveniles, 0.63g, origin AK
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 650 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 1050-2600; test on7-8w old juveniles,0.94g, origin AK
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
727 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 507-1042; test on alevins, origin WA
Reported statistics and error estimates:
The method of Litchfield and Wilcoxon was used to calculate the LC50 values and 95%C.I.
signnificant differences between LC50 values were determined by the standard error of the differences as described by Sprague and Fogels 1977.
Validity criteria fulfilled:
yes
Conclusions:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity.
Executive summary:

Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification. LC50 values: see “results” section.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification.zinc concentrations in test however not measured.
Qualifier:
according to guideline
Guideline:
other: American Society for testing materials 1988: Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians, ASTM, E-729-88, Philadelphia
GLP compliance:
not specified
Analytical monitoring:
no
Details on sampling:
no data
Vehicle:
no
Details on test solutions:
standard reconstituted soft water (EPA 1975)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
organisms from Ennis national fish hatchery Ennis, Montana (code: MT)
Test type:
static
Water media type:
freshwater
Limit test:
no
Hardness:
41 mg CaCO3/l
Test temperature:
12 +/-1°C
pH:
7.1-8.0
Nominal and measured concentrations:
no details given, nominal concentrations reported
Details on test conditions:
different life stages were tested
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2 170 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.I.: 1850-2550; test on alevins, origin code MT
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
169 µg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Remarks on result:
other: 95%C.I. 118-243; test on 7-10w old juveniles, 0.6g, code MT
Reported statistics and error estimates:
The method of Litchfield and Wilcoxon was used to calculate the LC50 values and 95%C.I.
signnificant differences between LC50 values were determined by the standard error of the differences as described by Sprague and Fogels 1977.
Validity criteria fulfilled:
yes
Conclusions:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity.
Executive summary:

Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. Study used for that purpose in the EU risk assessment process on zinc (ECB 2008). Culture medium, test water conditions well described and relevant the purpose of classification. LC50 values: see “results” section.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1929
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from HSDB database. Peer reviewed.
Guideline:
other: Not specified
Principles of method if other than guideline:
Conditions of bioassay not specified
GLP compliance:
not specified
Specific details on test material used for the study:
No data
Analytical monitoring:
not specified
Details on sampling:
No data
Vehicle:
not specified
Details on test solutions:
No data
Test organisms (species):
Oncorhynchus kisutch
Details on test organisms:
Oncorhynchus kisutch (coho salmon)
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
286 µg/L
Basis for effect:
mortality (fish)
Details on results:
No further information
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
not specified
Conclusions:
In an experimental study where the toxicity of the substance copper dibromide on the coho salmon Oncorhynchus kisutch was assessed, the 96h-LC50 was determined to be 286 ug/L.
Executive summary:

In an experimental study where the toxicity of the substance copper dibromide on the coho salmon Oncorhynchus kisutch was assessed, the 96h-LC50 was determined to be 286 ug/L.

Description of key information

In an experimental study where the toxicity of the substance copper dibromide on the coho salmon Oncorhynchus kisutch was assessed, the 96h-LC50 was determined to be 286 ug/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
286 µg/L

Additional information

Supporting studies on an analogue substance having the same chemical structure (geometry) were added and gave 96h-LC50 between 166 and 2920 ug/L.