Registration Dossier
Registration Dossier
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EC number: 230-022-8 | CAS number: 6915-15-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Data are available from in-vitro tests of both gene mutation and cytogenicity on both malic acid and fumaric acid. Read across between malic acid and fumaric acid is considered valid as metabolism of fumaric acid to malic acid occurs as a key part of the Krebbs Cycle
Short description of key information:
Genotoxicity in-vitro: Negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on results of the three different in vitro genetic toxicity studies, classification and labelling as genotoxic according to Directive 67/548/EEC (DSD) and to Regulation 1272/2008/EC (CLP) is not indicated.
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