Registration Dossier
Registration Dossier
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EC number: 230-022-8 | CAS number: 6915-15-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Biodegradation: readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Malic acid is readily biodegradable, as determined by the outcome of a Modified MITI Test conducted according to OECD TG 301 C on dl-malic acid. It is noted that,in a revision of the practices regarding stereochemical practices, racemic mixtures of substances having single chiral centers are now indexed, registered, and named as non-stereospecific substances with the racemate distinction being discontinued. Thus, DL-malic acid and malic acid (stereospecificity unspecified) now receive the same CAS Registry Number and CA index name: 6915-15-7, Butanedioic acid, hydroxy-. Experimental findings are supported by Q(S)AR assessment.
In addition, fumaric acid is readily biodegradable. Read across from fumaric acid to malic is considered valid as the metabolic route for fumaric acid is through malic acid. Therefore, to achieve biodegradation in excess of 60% implies that malic acid is also readily biodegradable. Fumaric acid is less water soluble and also requires one further metabolic step than malic acid; it is likely that malic acid biodegrades faster, evidenced by the experimental findings.
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