Registration Dossier
Registration Dossier
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EC number: 224-631-8 | CAS number: 4431-83-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
ABSORPTION
Oral / gastrointestinal absorption
With a low molecular weight (164.20 g/mol), high water solubility (1000 g/L) and log Kow of -0.69, oral/gastrointestinal absorption of TOU is favoured subsequent to oral ingestion. Log Kow values between -1 and 4 are favourable for absorption by passive diffusion.
Oral absorption of TOU is set to 100% for risk assessment
Inhalation absorption
TOU is a substance with a medium volatility but may be available for inhalation as a vapour. Its moderate log Kow value is favourable for absorption directly across the respiratory tract epithelium by passive diffusion. High solubility of TOU in water indicates that it may be retained within the mucus.
Inhalation absorption of TOU is set to 100% for risk assessment.
Dermal absorption
As a liquid with a molecular weight close to 100 g/mol, TOU dermal uptake is favoured.
Based on molecular weight < 500 and log Kow in the (-1, 4) range, default dermal absorption of TOU is set to 100% for risk assessment.
Dermal absorption of TOU is set to 100% for risk assessment.
DISTRIBUTION
A wide distribution is expected due to the low molecular weight. As a small water-soluble molecule, TOU is going to diffuse through aqueous channels and pores.
METABOLISM and EXCRETION
TOU is not considered as substance with a potential to accumulate within the body. The liver is known to be the greatest capacity for metabolism and the 28-day dermal study shows no significant increases in liver weights of male and female rats exposed to 1000 mg/kg bw/d of TOU.
The following values for absorption assessment were taken into account according to TOU behaviour (absorption, metabolism, distribution and elimination):
oral absorption of TOU is set to 100% for risk assessment;
inhalation absorption of TOU is set to 100% for risk assessment;
dermal absorption of TOU is set to 100% for risk assessment.
At more, no bioaccumulation potentiel is expected due to the low log Kow value of the test item.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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