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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

According to column 1 of REACH annex VII and VIII, in vitro gene mutation study in bacteriaIn (8.4.1), in vitro cytogenicity study in mammalian cells or in vitro micronucleus study (8.4.2) and in vitro gene mutation study in mammalian cells (8.4.3) are required.

As the three tests show a negative result, the test substance is not genotoxic.

According to column 2 of REACH annex IX, as no positive result in any of the in vitro genotoxicity studies in Annex VII

or VIII a, in vivo somatic cell genotoxicity study is not required.

Justification for selection of genetic toxicity endpoint

The OECD TG 476 test was selected as the last test required by REACH for mutagenicity whereas OECD TG 471 and 487 tests are also required.

Short description of key information:

Three tests were performed to assess the genotoxicity potential of the test substance with a negative result in these three tests:

- OECD TG 471 - Bacterial Reverse Mutation Test

- OECD TG 487 - In Vitro Mammalian Cell Micronucleus Test

- OECD TG 476 - In vitro Mammalian Cell Gene Mutation Test

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

With a negative result in the 3 required studies, the test substance is not classified for its genotoxic potential.