Registration Dossier
Registration Dossier
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EC number: 218-465-5 | CAS number: 2157-01-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Principles of method if other than guideline:
- Method: (measured): shake-flask
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 22-902-13914-28
- Purity: > 98 % - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.24
- Temp.:
- 20 °C
- pH:
- ca. 6
- Conclusions:
- Using a valid scientific method (shake-flask method) the partition coefficient of the substance is 5.24 at 20°C.
The capability range of the method is logKow from 0 to 4. This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category. - Executive summary:
Using a valid scientific method (shake-flask method) the partition coefficient of the substance is 5.24 at 20°C.
The capability range of the method is logKow from 0 to 4. This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Description of key information
logPow 5.24 at 20°C, Jones 2002; OECD 107 (supported by lower alkyl methacrylate category QSPR)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.24
- at the temperature of:
- 20 °C
Additional information
In the key study a logPow value of 5.24 has been determined (Jones, 2002). This is at the limit of the extended reliability range for this method but also consistent with a QSPR based on the lower alkyl methacrylate category.
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