Registration Dossier
Registration Dossier
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EC number: 218-465-5 | CAS number: 2157-01-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not known
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Octyl methacrylate
- EC Number:
- 218-465-5
- EC Name:
- Octyl methacrylate
- Cas Number:
- 2157-01-9
- Molecular formula:
- C12H22O2
- IUPAC Name:
- octyl 2-methylprop-2-enoate
- Details on test material:
- Octyl methacrylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderly Park
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 hours/day
- Frequency of treatment:
- 5 days/week, 3 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
saturated, 2 male and 2 female rats/dose
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 24 hours
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Haematological findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Neuropathological findings:
- not examined
- Details on results:
- saturated: no signs of toxicity; no findings at autopsy, organs normal
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a published study there were no signs of toxicity; no findings at autopsy, normal organs at a saturated atmosphere.
- Executive summary:
No overt signs of toxicity were observed in a screening study in which groups of four rats (2 males and 2 females) exposed to Octyl methacrylate vapour (saturated atmosphere) for 6 hr/day, five days per week, over 3 weeks.
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