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EC number: 218-465-5 | CAS number: 2157-01-9
The results of the whole-skin penetration studies and the model predictions for
other methacrylate esters are presented in the table.
Table: Summary of the results for the peak rates of absorption of MAA & alkylmethacrylate esters through rat & human epidermis
Peak rate of absorption (μg cm-2hr-1) ±SEM
Period of peak absorption rate (hours)
% age of applied dose absorbed over x hours
93% / 24h
46% / 16h
10% / 24h
18% / 24h
2% / 24h
7.8% / 30h
0.6% / 24h
Ester Peak = rate of appearance of the parent ester (µg/cm2/hr) MAA Peak = rate of appearance of the hydrolysis product, MAA (µg/cm2/hr) Period Peak Absorp. = Time (hours) after application for peak absorption % Applied Dose = total % absorbed ** Predicted rates of MAA from model estimates.
Summary of the peak rates of absorption of MAA & alkyl-methacrylate esters through whole rat and human skin
Rat whole rat
Human whole skin
Peak rate of appearance (µg*cm-2*h-1)+- SEM
% age of
over x hours
The values in normal type were obtained experimentally, whilst those in italics are predicted values.
** Values are predicted rates of appearance of total chemical including parent ester and metabolite
The absorption of Octyl methacrylate (OMA) was evaluated through rat and human epidermis in an in vitro system. The technique measures the rate of absorption of OMA across the epidermis. Glass diffusion cells are employed to measure the amount of OMA that is received into a receptor chamber with respect to time, following the application of 100 µl/cm² of OMA to the epidermal surface. OMA absorbed at a constant rate throughoutr the period of exposure/sampling (0 -24 hours). The mean rate of absorption was calculated 159 µg cm-2 hr-1 and the total amount of chemical that was absorbed during the time of exposure was 4.2% (over 24 hours), respectively. OMA appears readily absorbed through rat and human epidermis, but human epideremisc is several times less permeable to OMA than rat epidermis. However, measuring the rate of absorption through rat and human epidermis provides a quantitative estimate for inter-species differences; however, because only the epidermal layer is used, no measure of metabolism during skin absorption is possible.
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