Registration Dossier
Registration Dossier
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EC number: 210-236-8 | CAS number: 610-81-1
Endpoint summary
Administrative data
Description of key information
According to GHS and CLP classification, the test item is irritating to eyes, cat2 in CLP and 2B in GHS.
Key value for chemical safety assessment
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In order to assess the potential eye irritating property of the test article, one key study is available :
Dufour, 1996, Klimisch 2, OECD 405 guideline :
In this study, 3 New Zealand white male rabbits were used. A 0.1 g of undiluted test item was instilled into the conjunctival sac of the right eye of the animals and the eyes were not rinsed after administration of the test substance. The untreated left eye served as control, and the ocular reactions were assessed 1, 24, 48 and 72 hours after instillation. One hour after instillation of the substance at the dose of 0.1 g in the eye of 3 rabbits, it occurs in all animals irritations of the palpebral and bulbar conjunctivae. An orange coloration induced by the product did not make it possible to perform all the readings. 24 hours later an important redness, slight discharge and slight to important chemosis are observed in all animals. An iris congestion and a partial corneal opacity are also noticed. iris congestion and corneal opacity are totally reversible in less than 72 hours. Conjunctival reactions disappeared within about a week. According to GHS and CLP classification, the test item is irritating to eyes, cat2 in CLP and 2B in GHS.
Justification for classification or non-classification
According to GHS and CLP classification, the test item is irritating to eyes, cat2 in CLP and 2B in GHS.
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