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EC number: 276-038-9
CAS number: 71808-53-2
The 21d NOEC reproduction of 268 µg/L for daphnia is determined in a test according to OECD TG 211 (GLP). The 21d EC50 for parental mortality was 465 µg/L in the same test. The NOEC is based on active ingredient.
The Daphnia magna Reproduction Test with natural river water
(Semi-Static, 21 d) of Quaternary ammonium compounds,
C12-18-alkylbis(hydroxyethyl)methyl, chlorides was conducted according
to OECD 211 (Noack, 2010).10 test organisms were used per
concentration and control. At test start they were 2 to 24 hours old.All
concentrations and control were analytically verified at four sampling
dates with LC-MS/MS.
The reproduction was not significantly increased or decreased at
exposure concentrations ranging from 10 – 270 µg/L. At the highest test
concentration of 810 µg/L no reproduction was observed due to mortality
of the adult daphnids. The NOEC reproduction is therefore 270 µg/L.
Significant adult mortality (100%) was observed at the highest
test concentration , while in the other test concentrations and in the
control no significant mortality occurred. The EC50 for parental
mortality is 468 µg/L (95% C.I. 270 – 810 µg/L)
calculated as the geometric mean of the lowest concentration causing
100% mortality (810 µg/l) and the highest concentration causing 0%
mortality (270 µg/L) because only 0% and 100% mortality was observed in
The NOEC reproduction was 270 µg/L determined after 21 days. The
EC50parental mortality was 468 µg/L determined after 21 days of
exposure. The latter value is used as worst-case acute EC50 for aquatic
invertebrates in the hazard assessment in the absence of reliable acute
data.The effects are expressed as nominal values because the
tests were performed with river water as they are intended to be used in
an evaluation of the environmental risks based on the Bulk approach. The
NOEC for reproduction is 268 µg/L based on active ingredient (99.4%).
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