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EC number: 276-038-9
CAS number: 71808-53-2
The EC50 daphnia is 468 µg/L based on test material, derived from a 21d-daphnia test according to OECD TG 211. The EC50 is 465 µg/L converted to active ingredient content.
For Quaternary ammonium compounds,
C12-18-alkylbis(hydroxyethyl)methyl as registered, no studies on the
acute toxicity to aquatic invertebrates are available. The 21d-EC50
determined in a long term OECD 211 test (reliability 1) is used as a
worst case key value for the short term toxicity to aquatic
invertebrates. Furthermore, read-across is used as supporting
information for this endpoint. The two supporting studies (OECD 202) are
performed with quaternary ammonium compound C12 and quaternary ammonium
compound C14 (both reliability 4, because no GLP, no certificates of
analysis of the technical products were available, nominal
concentrations based on test material).
The two read-across studies were conducted in a period when no
reliable specific method of analyses was available. The concentrations
were therefore not analytically verified. The substance is known for its
poor water solubility and the strong tendency to adsorb onto the walls
of test vessels. Therefore it was decided to perform a number of higher
tier chronic invertebrate studies with analytical monitoring of the test
concentrations. These higher tier tests were performed in river water to
allow a PECaquatic,bulk/PNECaquatic,bulk approach for the environmental
risk assessment. The long
term 21d-EC50 for parental mortality determined in the OECD211 test with
river water (reliability 1) was used as the key value for acute toxicity
for daphnia in the chemical safety assessment.
The 21d-EC50 of 468 ug/l was determined according to OECD TG 211.The
study was assigned reliability 1 as all validation criteria were
fulfilled (GLP,complete identification of test substance,
including chemical analyses). The effects are expressed as nominal
values because the tests were performed with river water as they are
intended to be used in an evaluation of the environmental risks based on
the bulk approach. Further experimental details of the key study are
described in the section on long term toxicity to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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