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EC number: 276-038-9
CAS number: 71808-53-2
The results of a CAS test (OECD 303A, GLP, reliability 1) demonstrate that the substance is removed by > 99.99% from the waste water in conventional biological waste water treatment plants. Chemical analysis of the test substance confirmed that removal occured primarily via biodegradation.
In accordance with column 2 (126.96.36.199) of REACH (Regulation 1907/2006/EC) Annex IX, simulation testing on biodegradation in water and sediment is not needed as the substance is readily biodegradable.
in STP (OECD 303A)
of organic substances in biological wastewater treatment systems is
mainly determined by their biodegradability, capacity to adsorb, and
evaporation.SimpleTreat does integrate adsorption, stripping and
biodegradation (Struijset al., 1991, Struijs, 1996). The
justification of read-across of removal of organic substances from
wastewater in biological treatment systems should therefore be based on
these properties. The fate of Quaternary
ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl in
wastewater treatment systems is assessed through read across with di
(2-hydroxy ethyl) oleyl amine. The removal of di (2-hydroxy ethyl) oleyl
amine has been determined in a CAS test.
removal of the readily biodegradable di (2-hydroxyl ethyl)
oleyl amine (CAS no: 25307-17-9) in
biological treatment plants was assessed in continuously-fed activated
sludge (CAS) unit fed with domestic wastewater spiked with di
(2-hydroxyl ethyl) oleyl amine (Akzo Nobel, 2010). Di (2-hydroxyl ethyl)
oleyl amine was exposed to micro-organisms maintained by addition of
domestic wastewater in the CAS test. Di (2-hydroxyl ethyl) oleyl amine was
spiked at nominal influent concentrations of 50 mg/L (37.0 mg/L carbon;
calculated) for a period of 48d and included a control fed with domestic
mean carbon removal percentage of di (2- hydroxyl ethyl) oleyl amine
calculated over 15 measurements of the test was 102± 0.8% (95%
confidence interval). These high removal percentages strongly indicate
that di (2-hydroxyl ethyl) oleyl amine is biodegraded completely.
Formation of water soluble compounds during biological treatment of di
(2-hydroxyl ethyl) oleyl amine can be excluded. An accurate assessment
of the removal of di (2-hydroxyl ethyl) oleyl amine was established with
specific analyses. The mean removal percentage of di (2-hydroxyl ethyl)
oleyl amine in the test unit was >99.999% using octadecenyl di
(2-hydroxyethyl) amine as most representative component. These analyses
demonstrate that the removal of di (2-hydroxyl ethyl) oleyl amine is
complete. Mean removal percentages of octadecenyl bis(2-hydroxyethyl)
amine from the influent through adsorption onto sludge assessed in two
samples was 0.16% demonstrating that octadecenyl bis(2-hydroxyethyl)
amine is primarily removed by biodegradation.
conclusion, the CAS test demonstrates that di (2-hydroxyl ethyl) oleyl
amine is almost completely removed from the wastewater in conventional
biological wastewater treatment plants. Di (2-hydroxyl ethyl) oleyl
amine is primarily removed by biodegradation.
biodegradability, capacity to adsorb and evaporation of the two
ethoxylated amine derivatives are given in the Table below. Both
derivatives have been classified as readily biodegradable. The Henry’s
Law constants of the surfactants demonstrate that evaporation is
negligible. The Log Koc indicates that the potential of Quaternary
ammonium compounds, C12 -18 -alkylbis(hydroxyethyl)methyl to
ammonium compounds, C12 -18 -alkylbis(hydroxyethyl)methyl
total removal percentage of >99.9 is adopted as a worst-case for Quaternary
ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl.
The adopted worst-case removal via sorption is <0.16% based on the lower
sorption of Quaternary
ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl when
compared to di (2- hydroxyl ethyl) oleyl amine.
Biodegradability test results (OECD 301 D), Henry’s law constant and the
Log Koc of the ethoxylated fatty amine derivatives and removal
percentages of di (2- hydroxy ethyl) oleyl amine determined in CAS tests
(OECD 303A). The removal percentages of Quaternary
ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl as registered obtained
through read across are indicated in bold.
Henry’s Law constant
(Potential to adsorb)
Total removal in CAS test
Removal via sorption in CAS test
Di (2- hydroxy ethyl) oleyl amine
(CAS no: 25307-17-9)
1.215 * 10-5(calculated EPI)
0.071 (calculated from ratio measured VP/CMC)
Log Koc = 3.70 (calculated, EPI)
Log Koc = 4.96 (measured, range 4.61 – 4.97)
Quaternary ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl, chloride(CAS no: 71808-53-2)
1.453 * 10-12(calculated EPI)
7.8 * 10‑4(calculated from ratio measured VP/CMC)
Log Koc = 2.16 (calculated, EPI)
Log Koc = 4.6
(measured, range 3.88 – 4.81)
<0.16(worst-case in relation to measured Koc)
the Henry’s law constant is in the range 10-2< H < 1
Pa.m3/ mol, the test substance volatilizes slowly at a rate
dependent on the Henry’s law constant. If the Henry’s law constant is in
the range 1 < H < 102Pa.m3/mol, the test
substance volatilizes not rapid but possibly significant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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