Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 270-984-6 | CAS number: 68512-62-9 A complex residuum from the vacuum distillation of the residuum from the atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: RELIABLE SUMMARY REPORT
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON HEAVY FUEL OILS
- Author:
- AMERICAN PETROLEUM INSTITUTE
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON HEAVY FUEL OILS PG 50
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BUEHLER TEST
- Deviations:
- not specified
- Principles of method if other than guideline:
- METHOD BUEHLER TEST
- GLP compliance:
- not specified
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Gas oils (petroleum), heavy vacuum
- EC Number:
- 265-058-3
- EC Name:
- Gas oils (petroleum), heavy vacuum
- Cas Number:
- 64741-57-7
- IUPAC Name:
- 64741-57-7
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- 0.5 ml diluted (1:2 in mineral oil) test material w as applied under occlusion to the shorn skin of 10 guinea pigs.
Challengeopen allclose all
- Route:
- other: MINERAL OIL
- Concentration / amount:
- 0.5 ml diluted (1:2 in mineral oil) test material w as applied under occlusion to the shorn skin of 10 guinea pigs.
- No. of animals per dose:
- 10
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: SEE NY OTHER INFORMATION ON RESULTS INCL. TABLES
- Remarks on result:
- other: Reading: other: SEE NY OTHER INFORMATION ON RESULTS INCL. TABLES.
Any other information on results incl. tables
The following responses were recorded.
Group Incidence Severity
HVGO test group 1/10 0.1&0.0
HVGO challenge control 0/4 0.3&0.0
Positive control 10/10 3.6&3.3
DNCB challenge control 0/4 1.0&0.0
These data demonstrate that the test material is not a skin sensitizer.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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