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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 89-62-3
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
other: Acute Rodent Inhalation Toxicity Test;standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-nitro-p-toluidine
EC Number:
201-924-9
EC Name:
2-nitro-p-toluidine
Cas Number:
89-62-3
Molecular formula:
C7H8N2O2
IUPAC Name:
4-methyl-2-nitroaniline
Details on test material:
- Name of test material: 2-nitro-p-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.15
- Substance type: organic

SMILES:c1(N)c(N(=O)=O)cc(C)cc1

Test animals

Species:
rat
Strain:
other: Wistar;CnR-CD;Sprague-Dawley;Long-Evans;no data
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
other: Inhalation: Vapor
Vehicle:
not specified
Duration of exposure:
4 h
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
19.317 other: mg/L
Based on:
test mat.
Exp. duration:
4 h

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

("a" and ("b" and "c" and "d" and "e" ) )

Domain logical expression index: "a"

Similarity boundary:Target: c1(N)c(N(=O)=O)cc(C)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.15

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.2

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of Molecular weight which is >= 137 Da

Domain logical expression index: "e"

Parametric boundary:The target chemical should have a value of Molecular weight which is <= 168 Da

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 4 hr acute inhalation median lethal concentration (LC50) of 2-nitro-p-toluidine in rat was estimated to be 19.31692 mg/L. Acute inhalation toxicity of 2-nitro-p-toluidine to rat by inhalative route indicates that the substance exhibits acute toxicity Category IV type by the inhalative route.
Executive summary:

The 4 hr acute inhalation median lethal concentration (LC50) of 2-nitro-p-toluidine in rat was estimated to be 19.31692 mg/L. Acute inhalation toxicity of 2-nitro-p-toluidine to rat by inhalative route indicates that the substance exhibits acute toxicity Category IV type by the inhalative route.