Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only few data given in TSCA8e information, but no actual study report. Basic information missing.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Report date:
1970

Materials and methods

Principles of method if other than guideline:
Single i.p. administration to mice
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloro(phenyl)phosphine
EC Number:
211-425-8
EC Name:
Dichloro(phenyl)phosphine
Cas Number:
644-97-3
Molecular formula:
C6H5Cl2P
IUPAC Name:
dichloro(phenyl)phosphine

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
100 - 1600 mg/kg bw
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
< 100 mg/kg bw
Remarks on result:
other: Sl. to very wk. - rough coat - sl. tremor.

Applicant's summary and conclusion